The aim of this “Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori” study was to functionally characterize the role of autophagy in Helicobacter pylori infection, one of the most prevalent infectious pathogens in the world and a major trigger for pathological changes in the gastric mucosa, including gastritis, intestinal metaplasia, dysplasia and adenocarcinoma. Findings show that the disruption of autophagosome formation can be a novel strategy to reduce Helicobacter pylori colonization in human stomachs (J Pathol. 2018 Jan 12. doi: 10.1002/path.5033. [Epub ahead of print]).
Anyone interested in future collaboration in this field of research is welcome to contact our key investigator Prof William Wu of our Department of Anaesthesia and Intensive Care. Prof Wu’s research interests include autophagy, cancer biology, sepsis and translational genomics; and he has published over 150 peer-reviewed articles in major international journals.